Modulating cell-to-cell variability and sensitivity to death ligands by co-drugging
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چکیده
منابع مشابه
Modulating cell-to-cell variability and sensitivity to death ligands by co-drugging.
TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) holds promise as an anti-cancer therapeutic but efficiently induces apoptosis in only a subset of tumor cell lines. Moreover, even in clonal populations of responsive lines, only a fraction of cells dies in response to TRAIL and individual cells exhibit cell-to-cell variability in the timing of cell death. Fractional killing in the...
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ژورنال
عنوان ژورنال: Physical Biology
سال: 2013
ISSN: 1478-3967,1478-3975
DOI: 10.1088/1478-3975/10/3/035002